At Columbia Biosciences, we develop and manufacture fluorescent proteins, antibody conjugates and novel protein purification ligands. Our comprehensive custom services include antibody labeling, protein purification, and discovery services such as functional cell based assays for pre-clinical drug development in oncology and immunology. We also provide consulting services for experimental design and execution of preclinical in vitro and in vivo research strategies.
Our expertise lies in the ability to integrate microalgae cultures with the isolation and purification of algal fluorophores, and with the conjugation of these and other fluorophores to antibodies. Many manufacturers harvest algae from the ocean or ponds, which can be subject to variability due to weather and shipping conditions. We culture our own proprietary strains under controlled conditions assuring product integrity, reproducibility and uninterrupted supply at competitive prices.
We produce a variety of fluorescently labeled streptavidin and anti-epitope tag antibody conjugates using APC, PE, PerCP, DyLight® and associated tandem dyes. Applications include TR-FRET-based High Throughput Screening assays (HTS), Flow Cytometry and Fluorescent Microscopy.
We offer custom protein/antibody labeling services using PE, APC, PerCP, FITC, Texas Red, DyLight® dyes, Cy Dyes, biotin, streptavidin, alkaline phosphatase (AP), horseradish peroxidase (HRP) and other biomolecules. Our contract services team will work with you to label, purify and lyophilize proteins to your specifications. Current customers include pharmaceutical and biotechnology companies, diagnostic companies, academia and US government laboratories.
Our products are sold through the leading laboratory distributors, including Fisher Scientific, VWR, PerkinElmer, Cayman Chemical, Funakoshi, CosmoBio, and 2bScientific.
We are member of the Pivotal Scientific Alliance.